7tze

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==LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition==
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==Structure of murine LAG3 domains 1-2==
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<StructureSection load='7tze' size='340' side='right'caption='[[7tze]]' scene=''>
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<StructureSection load='7tze' size='340' side='right'caption='[[7tze]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TZE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7tze]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TZE FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tze OCA], [https://pdbe.org/7tze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tze RCSB], [https://www.ebi.ac.uk/pdbsum/7tze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tze ProSAT]</span></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tze OCA], [https://pdbe.org/7tze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tze RCSB], [https://www.ebi.ac.uk/pdbsum/7tze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tze ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/LAG3_MOUSE LAG3_MOUSE]] Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:12209638, PubMed:12421911, PubMed:12672063, PubMed:15100286, PubMed:15634887, PubMed:30580966). Delivers inhibitory signals upon binding to ligands, such as FGL1 (PubMed:30580966). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (PubMed:12209638, PubMed:12421911, PubMed:12672063, PubMed:15100286, PubMed:15634887). May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (PubMed:21300912). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells (PubMed:12209638, PubMed:12421911, PubMed:12672063, PubMed:15100286, PubMed:15634887). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (PubMed:15485628). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (PubMed:19201841). Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear (PubMed:12209638, PubMed:12421911, PubMed:15634887).<ref>PMID:12209638</ref> <ref>PMID:12421911</ref> <ref>PMID:12672063</ref> <ref>PMID:15100286</ref> <ref>PMID:15485628</ref> <ref>PMID:15634887</ref> <ref>PMID:19201841</ref> <ref>PMID:21300912</ref> <ref>PMID:30580966</ref> May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response.<ref>PMID:11937541</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Luca VC]]
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[[Category: Luca, V C]]
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[[Category: Ming Q]]
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[[Category: Ming, Q]]
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[[Category: Tran TH]]
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[[Category: Tran, T H]]
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[[Category: Ig-like fold]]
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[[Category: Immune checkpoint]]
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[[Category: Immunosuppressant]]
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[[Category: T cell]]

Revision as of 10:28, 18 May 2022

Structure of murine LAG3 domains 1-2

PDB ID 7tze

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