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3ont
From Proteopedia
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==The Crystal Structure of Spot14, a modulator of lipogenesis== | ==The Crystal Structure of Spot14, a modulator of lipogenesis== | ||
| - | <StructureSection load='3ont' size='340' side='right' caption='[[3ont]], [[Resolution|resolution]] 2.65Å' scene=''> | + | <StructureSection load='3ont' size='340' side='right'caption='[[3ont]], [[Resolution|resolution]] 2.65Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3ont]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3ont]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ONT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ONT FirstGlance]. <br> |
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S14, spot14, Thrsp ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S14, spot14, Thrsp ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ont FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ont OCA], [https://pdbe.org/3ont PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ont RCSB], [https://www.ebi.ac.uk/pdbsum/3ont PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ont ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/THRSP_MOUSE THRSP_MOUSE]] Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA. May function as transcriptional coactivator. May modulate the transcription factor activity of THRB (By similarity).<ref>PMID:15890771</ref> <ref>PMID:20952656</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Lk3 transgenic mice]] | [[Category: Lk3 transgenic mice]] | ||
[[Category: Colbert, C L]] | [[Category: Colbert, C L]] | ||
Revision as of 10:50, 18 May 2022
The Crystal Structure of Spot14, a modulator of lipogenesis
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