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3otd

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==Crystal structure of human tRNAHis guanylyltransferase (Thg1)- NaI derivative==
==Crystal structure of human tRNAHis guanylyltransferase (Thg1)- NaI derivative==
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<StructureSection load='3otd' size='340' side='right' caption='[[3otd]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
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<StructureSection load='3otd' size='340' side='right'caption='[[3otd]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3otd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OTD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OTD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3otd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OTD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OTD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3otb|3otb]], [[3otc|3otc]], [[3ote|3ote]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3otb|3otb]], [[3otc|3otc]], [[3ote|3ote]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ICF45, THG1L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ICF45, THG1L ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3otd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3otd OCA], [http://pdbe.org/3otd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3otd RCSB], [http://www.ebi.ac.uk/pdbsum/3otd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3otd ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3otd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3otd OCA], [https://pdbe.org/3otd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3otd RCSB], [https://www.ebi.ac.uk/pdbsum/3otd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3otd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/THG1_HUMAN THG1_HUMAN]] Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis.<ref>PMID:21059936</ref>
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[[https://www.uniprot.org/uniprot/THG1_HUMAN THG1_HUMAN]] Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis.<ref>PMID:21059936</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Doublie, S]]
[[Category: Doublie, S]]
[[Category: Eckenroth, B E]]
[[Category: Eckenroth, B E]]

Revision as of 10:56, 18 May 2022

Crystal structure of human tRNAHis guanylyltransferase (Thg1)- NaI derivative

PDB ID 3otd

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