3p45
From Proteopedia
(Difference between revisions)
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==Crystal structure of apo-caspase-6 at physiological pH== | ==Crystal structure of apo-caspase-6 at physiological pH== | ||
| - | <StructureSection load='3p45' size='340' side='right' caption='[[3p45]], [[Resolution|resolution]] 2.53Å' scene=''> | + | <StructureSection load='3p45' size='340' side='right'caption='[[3p45]], [[Resolution|resolution]] 2.53Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3p45]] is a 16 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3p45]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P45 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P45 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP6 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p45 OCA], [https://pdbe.org/3p45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p45 RCSB], [https://www.ebi.ac.uk/pdbsum/3p45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p45 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. |
==See Also== | ==See Also== | ||
| - | *[[Caspase|Caspase]] | + | *[[Caspase 3D structures|Caspase 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Dominguez, C]] | [[Category: Dominguez, C]] | ||
[[Category: Kiselyov, A]] | [[Category: Kiselyov, A]] | ||
Revision as of 11:18, 18 May 2022
Crystal structure of apo-caspase-6 at physiological pH
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