3p76
From Proteopedia
(Difference between revisions)
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==X-ray crystal structure of Aquifex aeolicus LpxC complexed SCH1379777== | ==X-ray crystal structure of Aquifex aeolicus LpxC complexed SCH1379777== | ||
- | <StructureSection load='3p76' size='340' side='right' caption='[[3p76]], [[Resolution|resolution]] 1.93Å' scene=''> | + | <StructureSection load='3p76' size='340' side='right'caption='[[3p76]], [[Resolution|resolution]] 1.93Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[3p76]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3p76]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P76 FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=P76:N-[(1S,2R)-2-HYDROXY-1-(HYDROXYCARBAMOYL)PROPYL]-4-[4-(PHENYLETHYNYL)PHENYL]PIPERIDINE-1-CARBOXAMIDE'>P76</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=P76:N-[(1S,2R)-2-HYDROXY-1-(HYDROXYCARBAMOYL)PROPYL]-4-[4-(PHENYLETHYNYL)PHENYL]PIPERIDINE-1-CARBOXAMIDE'>P76</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p76 OCA], [https://pdbe.org/3p76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p76 RCSB], [https://www.ebi.ac.uk/pdbsum/3p76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p76 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
- | [[ | + | [[https://www.uniprot.org/uniprot/LPXC_AQUAE LPXC_AQUAE]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity). |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Aquifex aeolicus]] | [[Category: Aquifex aeolicus]] | ||
+ | [[Category: Large Structures]] | ||
[[Category: Orth, P]] | [[Category: Orth, P]] | ||
[[Category: Amidohydrolase]] | [[Category: Amidohydrolase]] |
Revision as of 11:22, 18 May 2022
X-ray crystal structure of Aquifex aeolicus LpxC complexed SCH1379777
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Categories: Aquifex aeolicus | Large Structures | Orth, P | Amidohydrolase | Amino acid motif | Binding site | Drug design | Enzyme inhibitor | Escherichia coli protein | Hydrolase | Hydrophobicity | Lipid some | Protein conformation | Protein folding | Recombinant fusion protein | Structure-activity relationship