This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
7zeg
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Human cytosolic 5' nucleotidase IIIB in complex with 3,4-diF-Bn7GMP== | ==Human cytosolic 5' nucleotidase IIIB in complex with 3,4-diF-Bn7GMP== | ||
| - | <StructureSection load='7zeg' size='340' side='right'caption='[[7zeg]]' scene=''> | + | <StructureSection load='7zeg' size='340' side='right'caption='[[7zeg]], [[Resolution|resolution]] 1.56Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZEG FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7zeg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZEG FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zeg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zeg OCA], [https://pdbe.org/7zeg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zeg RCSB], [https://www.ebi.ac.uk/pdbsum/7zeg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zeg ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOO:N7-(3,4-difluorobenzyl)+guanosine+5-monophosphate'>IOO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zeg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zeg OCA], [https://pdbe.org/7zeg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zeg RCSB], [https://www.ebi.ac.uk/pdbsum/7zeg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zeg ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/5NT3B_HUMAN 5NT3B_HUMAN]] Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate (PubMed:23223233, PubMed:24603684). The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids (PubMed:23223233). Also has weak activity for CMP (PubMed:23223233, PubMed:24603684). UMP and purine nucleotides are poor substrates (PubMed:23223233).<ref>PMID:23223233</ref> <ref>PMID:24603684</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Baranowski | + | [[Category: Baranowski, M R]] |
| - | [[Category: Basquin J]] | + | [[Category: Basquin, J]] |
| - | [[Category: Jemielity J]] | + | [[Category: Jemielity, J]] |
| - | [[Category: Kowalska J]] | + | [[Category: Kowalska, J]] |
| - | [[Category: Kozarski M]] | + | [[Category: Kozarski, M]] |
| - | [[Category: Kubacka D]] | + | [[Category: Kubacka, D]] |
| - | [[Category: Wojcik R]] | + | [[Category: Wojcik, R]] |
| + | [[Category: Cytosolic 5' nucleotidase]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Mrna cap degradation]] | ||
| + | [[Category: N7 methylguanosine monophosphate dephosphorylation]] | ||
Revision as of 08:19, 25 May 2022
Human cytosolic 5' nucleotidase IIIB in complex with 3,4-diF-Bn7GMP
| |||||||||||
