3pbl

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==Structure of the human dopamine D3 receptor in complex with eticlopride==
==Structure of the human dopamine D3 receptor in complex with eticlopride==
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<StructureSection load='3pbl' size='340' side='right' caption='[[3pbl]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
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<StructureSection load='3pbl' size='340' side='right'caption='[[3pbl]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3pbl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PBL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PBL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3pbl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PBL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ETQ:3-CHLORO-5-ETHYL-N-{[(2S)-1-ETHYLPYRROLIDIN-2-YL]METHYL}-6-HYDROXY-2-METHOXYBENZAMIDE'>ETQ</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ETQ:3-CHLORO-5-ETHYL-N-{[(2S)-1-ETHYLPYRROLIDIN-2-YL]METHYL}-6-HYDROXY-2-METHOXYBENZAMIDE'>ETQ</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DRD3, E ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DRD3, E ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pbl OCA], [http://pdbe.org/3pbl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pbl RCSB], [http://www.ebi.ac.uk/pdbsum/3pbl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pbl ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pbl OCA], [https://pdbe.org/3pbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pbl RCSB], [https://www.ebi.ac.uk/pdbsum/3pbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pbl ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN]] Hereditary essential tremor. Disease susceptibility is associated with variations affecting the gene represented in this entry.
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[[https://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN]] Hereditary essential tremor. Disease susceptibility is associated with variations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN]] Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.<ref>PMID:19520868</ref>
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[[https://www.uniprot.org/uniprot/DRD3_HUMAN DRD3_HUMAN]] Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.<ref>PMID:19520868</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Dopamine Receptors|Dopamine Receptors]]
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*[[Dopamine receptor|Dopamine receptor]]
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*[[Dopamine receptor 3D structures|Dopamine receptor 3D structures]]
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
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*[[Neurotransmitters|Neurotransmitters]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Lysozyme]]
[[Category: Lysozyme]]
[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure]]
[[Category: ATCG3D, Accelerated Technologies Center for Gene to 3D Structure]]

Revision as of 08:32, 25 May 2022

Structure of the human dopamine D3 receptor in complex with eticlopride

PDB ID 3pbl

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