This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3pjs
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Mechanism of Activation Gating in the Full-Length KcsA K+ Channel== | ==Mechanism of Activation Gating in the Full-Length KcsA K+ Channel== | ||
| - | <StructureSection load='3pjs' size='340' side='right' caption='[[3pjs]], [[Resolution|resolution]] 3.80Å' scene=''> | + | <StructureSection load='3pjs' size='340' side='right'caption='[[3pjs]], [[Resolution|resolution]] 3.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3pjs]] is a 8 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3pjs]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/"actinomyces_lividans"_krasil'nikov_et_al._1965 "actinomyces lividans" krasil'nikov et al. 1965] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PJS FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">kcsA, skc1 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">kcsA, skc1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1916 "Actinomyces lividans" Krasil'nikov et al. 1965])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pjs OCA], [https://pdbe.org/3pjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pjs RCSB], [https://www.ebi.ac.uk/pdbsum/3pjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pjs ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 20: | Line 20: | ||
==See Also== | ==See Also== | ||
| - | *[[Potassium | + | *[[Antibody 3D structures|Antibody 3D structures]] |
| - | *[[3D structures of antibody|3D structures of antibody]] | + | *[[Potassium channel 3D structures|Potassium channel 3D structures]] |
| + | *[[3D structures of non-human antibody|3D structures of non-human antibody]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 27: | Line 28: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Actinomyces lividans krasil'nikov et al. 1965]] | [[Category: Actinomyces lividans krasil'nikov et al. 1965]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Lk3 transgenic mice]] | [[Category: Lk3 transgenic mice]] | ||
[[Category: Cuello, L G]] | [[Category: Cuello, L G]] | ||
Revision as of 08:42, 25 May 2022
Mechanism of Activation Gating in the Full-Length KcsA K+ Channel
| |||||||||||
