1f42

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Revision as of 14:42, 12 November 2007

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spinqualitylabelsall models 1f42, resolution 2.5Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

THE P40 DOMAIN OF HUMAN INTERLEUKIN-12

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

Human interleukin-12 (IL-12, p70) is an early pro-inflammatory cytokine, comprising two disulfide-linked subunits, p35 and p40. We solved the, crystal structures of monomeric human p40 at 2.5 A and the human p70, complex at 2.8 A resolution, which reveals that IL-12 is similar to class, 1 cytokine-receptor complexes. They also include the first description of, an N-terminal immunoglobulin-like domain, found on the p40 subunit., Several charged residues from p35 and p40 intercalate to form a unique, interlocking topography, shown by mutagenesis to be critical for p70, formation. A central arginine residue from p35 projects into a deep pocket, on p40, which may be an ideal target for a small molecule antagonist of, IL-12 formation.

Disease

Known diseases associated with this structure: Asthma, susceptibility to OMIM:[161561], BCG and salmonella infection, disseminated OMIM:[161561], Psoriasis, susceptibility to OMIM:[161561]

About this Structure

1F42 is a Single protein structure of sequence from Homo sapiens with MNB as ligand. Full crystallographic information is available from OCA.

Reference

Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12., Yoon C, Johnston SC, Tang J, Stahl M, Tobin JF, Somers WS, EMBO J. 2000 Jul 17;19(14):3530-41. PMID:10899108

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