3plt

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==Crystal structure of Lsp1 from Saccharomyces cerevisiae==
==Crystal structure of Lsp1 from Saccharomyces cerevisiae==
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<StructureSection load='3plt' size='340' side='right' caption='[[3plt]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='3plt' size='340' side='right'caption='[[3plt]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3plt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PLT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PLT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3plt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PLT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PLT FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3kq1|3kq1]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3kq1|3kq1]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LSP1, YPL004C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LSP1, YPL004C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3plt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3plt OCA], [http://pdbe.org/3plt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3plt RCSB], [http://www.ebi.ac.uk/pdbsum/3plt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3plt ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3plt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3plt OCA], [https://pdbe.org/3plt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3plt RCSB], [https://www.ebi.ac.uk/pdbsum/3plt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3plt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LSP1_YEAST LSP1_YEAST]] Together with PIL1, main component of eisosomes, structures at the cell periphery underneath the plasma membrane that mark the site of endocytosis. Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase PKH1/PHK2 activity and regulating their downstream CWI pathways PKC1-MAP kinase pathway and protein kinase YPK1 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress.<ref>PMID:15016821</ref>
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[[https://www.uniprot.org/uniprot/LSP1_YEAST LSP1_YEAST]] Together with PIL1, main component of eisosomes, structures at the cell periphery underneath the plasma membrane that mark the site of endocytosis. Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase PKH1/PHK2 activity and regulating their downstream CWI pathways PKC1-MAP kinase pathway and protein kinase YPK1 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress.<ref>PMID:15016821</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Atcc 18824]]
[[Category: Atcc 18824]]
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[[Category: Large Structures]]
[[Category: Walther, T C]]
[[Category: Walther, T C]]
[[Category: Ziolkowska, N E]]
[[Category: Ziolkowska, N E]]

Revision as of 08:44, 25 May 2022

Crystal structure of Lsp1 from Saccharomyces cerevisiae

PDB ID 3plt

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