3pry
From Proteopedia
(Difference between revisions)
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==Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution== | ==Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution== | ||
| - | <StructureSection load='3pry' size='340' side='right' caption='[[3pry]], [[Resolution|resolution]] 2.28Å' scene=''> | + | <StructureSection load='3pry' size='340' side='right'caption='[[3pry]], [[Resolution|resolution]] 2.28Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3pry]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3pry]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PRY FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSP90AB1, HSP90B, HSPC2, HSPCB ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSP90AB1, HSP90B, HSPC2, HSPCB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pry OCA], [https://pdbe.org/3pry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pry RCSB], [https://www.ebi.ac.uk/pdbsum/3pry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pry ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/HS90B_HUMAN HS90B_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:16478993</ref> <ref>PMID:19696785</ref> |
==See Also== | ==See Also== | ||
| - | *[[Heat Shock | + | *[[Heat Shock Protein structures|Heat Shock Protein structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Ayinampudi, V]] | [[Category: Ayinampudi, V]] | ||
Revision as of 08:52, 25 May 2022
Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution
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Categories: Human | Large Structures | Arrowsmith, C H | Ayinampudi, V | Berridge, G | Bountra, C | Bullock, A | Chaikuad, A | Che, K H | Cooper, C D.O | Delft, F von | Edwards, A | Fedorov, O | Keates, T | Krojer, T | Muniz, J R.C | Phillips, C | Pilka, E | Structural genomic | Sharpe, T D | Thangaratnarajah, C | Vollmar, M | Weigelt, J | Yue, W W | Zimmermann, T | Chaperone | Heat shock protein | Hsp90b | Sgc
