3pv6

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==Crystal structure of NKp30 bound to its ligand B7-H6==
==Crystal structure of NKp30 bound to its ligand B7-H6==
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<StructureSection load='3pv6' size='340' side='right' caption='[[3pv6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='3pv6' size='340' side='right'caption='[[3pv6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3pv6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PV6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PV6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3pv6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PV6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3pv7|3pv7]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3pv7|3pv7]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NCR3, 1C7, LY117 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NCR3, 1C7, LY117 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pv6 OCA], [http://pdbe.org/3pv6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pv6 RCSB], [http://www.ebi.ac.uk/pdbsum/3pv6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pv6 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pv6 OCA], [https://pdbe.org/3pv6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pv6 RCSB], [https://www.ebi.ac.uk/pdbsum/3pv6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pv6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NR3L1_HUMAN NR3L1_HUMAN]] Triggers NCR3-dependent natural killer cell activation.<ref>PMID:19528259</ref> [[http://www.uniprot.org/uniprot/NCTR3_HUMAN NCTR3_HUMAN]] Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.<ref>PMID:10562324</ref> <ref>PMID:15784725</ref> <ref>PMID:18852879</ref>
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[[https://www.uniprot.org/uniprot/NR3L1_HUMAN NR3L1_HUMAN]] Triggers NCR3-dependent natural killer cell activation.<ref>PMID:19528259</ref> [[https://www.uniprot.org/uniprot/NCTR3_HUMAN NCTR3_HUMAN]] Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.<ref>PMID:10562324</ref> <ref>PMID:15784725</ref> <ref>PMID:18852879</ref>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Li, Y]]
[[Category: Li, Y]]
[[Category: Immune system]]
[[Category: Immune system]]
[[Category: Nk cell receptor]]
[[Category: Nk cell receptor]]
[[Category: Receptor-ligand complex]]
[[Category: Receptor-ligand complex]]

Revision as of 08:57, 25 May 2022

Crystal structure of NKp30 bound to its ligand B7-H6

PDB ID 3pv6

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