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3q0h
From Proteopedia
(Difference between revisions)
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==Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT)== | ==Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT)== | ||
| - | <StructureSection load='3q0h' size='340' side='right' caption='[[3q0h]], [[Resolution|resolution]] 1.70Å' scene=''> | + | <StructureSection load='3q0h' size='340' side='right'caption='[[3q0h]], [[Resolution|resolution]] 1.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3q0h]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3q0h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q0H FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TIGIT, VSIG9, VSTM3 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TIGIT, VSIG9, VSTM3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0h OCA], [https://pdbe.org/3q0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q0h RCSB], [https://www.ebi.ac.uk/pdbsum/3q0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q0h ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TIGIT_HUMAN TIGIT_HUMAN]] Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Almo, S C]] | [[Category: Almo, S C]] | ||
[[Category: Guo, H]] | [[Category: Guo, H]] | ||
Revision as of 09:04, 25 May 2022
Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT)
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