1h8a

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[[Image:1h8a.gif|left|200px]]
[[Image:1h8a.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1h8a |SIZE=350|CAPTION= <scene name='initialview01'>1h8a</scene>, resolution 2.23&Aring;
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The line below this paragraph, containing "STRUCTURE_1h8a", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1h8a| PDB=1h8a | SCENE= }}
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|RELATEDENTRY=[[1h88|1H88]], [[1h89|1H89]], [[1hjb|1HJB]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8a OCA], [http://www.ebi.ac.uk/pdbsum/1h8a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1h8a RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX3'''
'''CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX3'''
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[[Category: Ogata, K.]]
[[Category: Ogata, K.]]
[[Category: Tahirov, T H.]]
[[Category: Tahirov, T H.]]
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[[Category: amv]]
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[[Category: Amv]]
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[[Category: avian myeloblastosis virus]]
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[[Category: Avian myeloblastosis virus]]
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[[Category: bzip]]
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[[Category: Bzip]]
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[[Category: c-myb]]
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[[Category: C-myb]]
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[[Category: c/ebp]]
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[[Category: C/ebp]]
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[[Category: crystal structure]]
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[[Category: Crystal structure]]
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[[Category: protein-dna complex]]
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[[Category: Protein-dna complex]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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[[Category: transcription/dna]]
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[[Category: Transcription/dna]]
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[[Category: transforming protein]]
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[[Category: Transforming protein]]
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[[Category: v-myb]]
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[[Category: V-myb]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:33:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:59:50 2008''
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Revision as of 15:33, 2 May 2008

Image:1h8a.gif

Template:STRUCTURE 1h8a

CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX3


Overview

c-Myb, but not avian myeloblastosis virus (AMV) v-Myb, cooperates with C/EBP beta to regulate transcription of myeloid-specific genes. To assess the structural basis for that difference, we determined the crystal structures of complexes comprised of the c-Myb or AMV v-Myb DNA-binding domain (DBD), the C/EBP beta DBD, and a promoter DNA fragment. Within the c-Myb complex, a DNA-bound C/EBP beta interacts with R2 of c-Myb bound to a different DNA fragment; point mutations in v-Myb R2 eliminate such interaction within the v-Myb complex. GST pull-down assays, luciferase trans-activation assays, and atomic force microscopy confirmed that the interaction of c-Myb and C/EBP beta observed in crystal mimics their long range interaction on the promoter, which is accompanied by intervening DNA looping.

About this Structure

1H8A is a Protein complex structure of sequences from Avian myeloblastosis virus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter., Tahirov TH, Sato K, Ichikawa-Iwata E, Sasaki M, Inoue-Bungo T, Shiina M, Kimura K, Takata S, Fujikawa A, Morii H, Kumasaka T, Yamamoto M, Ishii S, Ogata K, Cell. 2002 Jan 11;108(1):57-70. PMID:11792321 Page seeded by OCA on Fri May 2 18:33:47 2008

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OCA

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