3q3j
From Proteopedia
(Difference between revisions)
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==Crystal structure of plexin A2 RBD in complex with Rnd1== | ==Crystal structure of plexin A2 RBD in complex with Rnd1== | ||
| - | <StructureSection load='3q3j' size='340' side='right' caption='[[3q3j]], [[Resolution|resolution]] 1.97Å' scene=''> | + | <StructureSection load='3q3j' size='340' side='right'caption='[[3q3j]], [[Resolution|resolution]] 1.97Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3q3j]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3q3j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q3J FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PLXNA2, KIAA0463, OCT, PLXN2, UNQ209/PRO235 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PLXNA2, KIAA0463, OCT, PLXN2, UNQ209/PRO235 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), RND1, RHO6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q3j OCA], [https://pdbe.org/3q3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q3j RCSB], [https://www.ebi.ac.uk/pdbsum/3q3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q3j ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/PLXA2_HUMAN PLXA2_HUMAN]] Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). [[https://www.uniprot.org/uniprot/RND1_HUMAN RND1_HUMAN]] Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.<ref>PMID:11095956</ref> |
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| + | ==See Also== | ||
| + | *[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]] | ||
| + | *[[Plexin|Plexin]] | ||
| + | *[[Rho GTPase 3D structures|Rho GTPase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
Revision as of 05:50, 8 June 2022
Crystal structure of plexin A2 RBD in complex with Rnd1
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Categories: Human | Large Structures | Arrowsmith, C H | Bountra, C | Buren, L | Crombet, L | Edwards, A M | Guan, X | Park, H | Structural genomic | Shen, L | Tempel, W | Tong, Y | Wang, H | Weigelt, J | Wernimont, A K | Zhang, N | Membrane protein-protein binding complex | Plexin | Ras-binding domain | Sgc | Small gtpase
