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3q91
From Proteopedia
(Difference between revisions)
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==Crystal Structure of Human Uridine Diphosphate Glucose Pyrophosphatase (NUDT14)== | ==Crystal Structure of Human Uridine Diphosphate Glucose Pyrophosphatase (NUDT14)== | ||
| - | <StructureSection load='3q91' size='340' side='right' caption='[[3q91]], [[Resolution|resolution]] 2.70Å' scene=''> | + | <StructureSection load='3q91' size='340' side='right'caption='[[3q91]], [[Resolution|resolution]] 2.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3q91]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3q91]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q91 FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3q90|3q90]], [[3q93|3q93]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3q90|3q90]], [[3q93|3q93]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUDT14, UGPP ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUDT14, UGPP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/UDP-sugar_diphosphatase UDP-sugar diphosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.45 3.6.1.45] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q91 OCA], [https://pdbe.org/3q91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q91 RCSB], [https://www.ebi.ac.uk/pdbsum/3q91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q91 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/NUD14_HUMAN NUD14_HUMAN]] Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose. |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: UDP-sugar diphosphatase]] | [[Category: UDP-sugar diphosphatase]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
Revision as of 05:58, 8 June 2022
Crystal Structure of Human Uridine Diphosphate Glucose Pyrophosphatase (NUDT14)
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Categories: Human | Large Structures | UDP-sugar diphosphatase | Arrowsmith, C H | Berg, S Van Der | Berglund, H | Bountra, C | Collins, R | Edwards, A M | Ekblad, T | Flodin, S | Flores, A | Graslund, S | Hammarstrom, M | Johansson, I | Karlberg, T | Kol, S | Kotenyova, T | Kouznetsova, E | Moche, M | Nordlund, P | Nyman, T | Persson, C | Structural genomic | Schuler, H | Schutz, P | Siponen, M I | Thorsell, A G | Tresaugues, L | Wahlberg, E | Weigelt, J | Welin, M | Hydrolase | Magnesium binding | Mutt-like | Nudix | Sgc
