Twinfilin

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[[2vac]] – hTwi-2 N-terminal ADF-H domain - human<br />
[[2vac]] – hTwi-2 N-terminal ADF-H domain - human<br />
[[2w0i]] – hTwi-2 C-terminal ADF-H domain (mutant) <br />
[[2w0i]] – hTwi-2 C-terminal ADF-H domain (mutant) <br />
 +
[[7ccc]] – hTwi-1 + F-actin-capping protein + actin<br />
[[2hd7]], [[2d8b]] – mTwi-1 C-terminal ADF-H domain – mouse - NMR<br />
[[2hd7]], [[2d8b]] – mTwi-1 C-terminal ADF-H domain – mouse - NMR<br />
[[1m4j]] – mTwi-1 N-terminal ADF-H domain <br />
[[1m4j]] – mTwi-1 N-terminal ADF-H domain <br />
[[6rsw]] – mTwi-1 C-terminal ADF-H domain + actin + CAP1<br />
[[6rsw]] – mTwi-1 C-terminal ADF-H domain + actin + CAP1<br />
 +
[[7ds2]] – mTwi-1 C-terminal + F-actin-capping protein<br />
 +
[[7ds4]] – mTwi-1 C-terminal (mutant) + F-actin-capping protein<br />
 +
[[7dsb]] – mTwi-1 C-terminal + F-actin-capping protein + myotrophin<br />
 +
[[7ds3]] – mTwi-2 + F-actin-capping protein<br />
[[6yp9]] – rTwi-1 C-terminal ADF-H domain + actin - rabbit<br />
[[6yp9]] – rTwi-1 C-terminal ADF-H domain + actin - rabbit<br />
[[3daw]] – rTwi-1 C-terminal ADF-H domain (mutant) + actin + ATP<br />
[[3daw]] – rTwi-1 C-terminal ADF-H domain (mutant) + actin + ATP<br />

Revision as of 08:09, 12 June 2022

Structure of twinfilin-1 C-terminal ADF-H domain (green) complex with actin (cyan), ATP and Ca+2 ion (green (PDB code 3daw)

Drag the structure with the mouse to rotate

3D structures of twinfilin

Updated on 12-June-2022

Domains: N-terminal ADF-H 1-142; C-terminal ADF-H 176-316


2vac – hTwi-2 N-terminal ADF-H domain - human
2w0i – hTwi-2 C-terminal ADF-H domain (mutant)
7ccc – hTwi-1 + F-actin-capping protein + actin
2hd7, 2d8b – mTwi-1 C-terminal ADF-H domain – mouse - NMR
1m4j – mTwi-1 N-terminal ADF-H domain
6rsw – mTwi-1 C-terminal ADF-H domain + actin + CAP1
7ds2 – mTwi-1 C-terminal + F-actin-capping protein
7ds4 – mTwi-1 C-terminal (mutant) + F-actin-capping protein
7dsb – mTwi-1 C-terminal + F-actin-capping protein + myotrophin
7ds3 – mTwi-2 + F-actin-capping protein
6yp9 – rTwi-1 C-terminal ADF-H domain + actin - rabbit
3daw – rTwi-1 C-terminal ADF-H domain (mutant) + actin + ATP
6k2f – Twi – Entamoeba histolytica

References

  1. ↑ Palmgren S, Vartiainen M, Lappalainen P. Twinfilin, a molecular mailman for actin monomers. J Cell Sci. 2002 Mar 1;115(Pt 5):881-6. PMID:11870207
  2. ↑ Li L, Liu L, Qu B, Li X, Gao X, Zhang M. Twinfilin 1 enhances milk bio-synthesis and proliferation of bovine mammary epithelial cells via the mTOR signaling pathway. Biochem Biophys Res Commun. 2017 Oct 21;492(3):289-294. doi:, 10.1016/j.bbrc.2017.08.130. Epub 2017 Aug 31. PMID:28864421 doi:http://dx.doi.org/10.1016/j.bbrc.2017.08.130
  3. ↑ Paavilainen VO, Oksanen E, Goldman A, Lappalainen P. Structure of the actin-depolymerizing factor homology domain in complex with actin. J Cell Biol. 2008 Jul 14;182(1):51-9. PMID:18625842 doi:10.1083/jcb.200803100

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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