1hac

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[[Image:1hac.jpg|left|200px]]
[[Image:1hac.jpg|left|200px]]
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{{Structure
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|PDB= 1hac |SIZE=350|CAPTION= <scene name='initialview01'>1hac</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1hac", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NDD:2,6-DICARBOXYNAPHTHALENE'>NDD</scene>
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|ACTIVITY=
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|GENE=
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{{STRUCTURE_1hac| PDB=1hac | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hac OCA], [http://www.ebi.ac.uk/pdbsum/1hac PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hac RCSB]</span>
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}}
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'''CROSSLINKED HAEMOGLOBIN'''
'''CROSSLINKED HAEMOGLOBIN'''
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[[Category: Kluger, R.]]
[[Category: Kluger, R.]]
[[Category: Schumacher, M A.]]
[[Category: Schumacher, M A.]]
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[[Category: erythrocyte]]
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[[Category: Erythrocyte]]
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[[Category: heme]]
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[[Category: Heme]]
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[[Category: oxygen transport]]
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[[Category: Oxygen transport]]
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[[Category: respiratory protein]]
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[[Category: Respiratory protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:38:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:01:09 2008''
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Revision as of 15:38, 2 May 2008

Image:1hac.jpg

Template:STRUCTURE 1hac

CROSSLINKED HAEMOGLOBIN


Overview

Hemoglobin has been a long-standing paradigm for understanding protein allostery. Here, the x-ray structures of two chemically crosslinked, fully liganded hemoglobins, alpha2beta82CA82beta and alpha2beta82ND82beta, are described at 2.3 A and 2.6 A resolution, respectively. Strikingly, these crosslinked hemoglobins assume intermediate conformations that lie between those of R and the controversial liganded hemoglobin state R2 rather than between R and T. Thus, these structures support only a T left and right arrow R left and right arrow R2 allosteric pathway and underscore the physiological importance of the R2 conformation.

About this Structure

1HAC is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Allosteric intermediates indicate R2 is the liganded hemoglobin end state., Schumacher MA, Zheleznova EE, Poundstone KS, Kluger R, Jones RT, Brennan RG, Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):7841-4. PMID:9223274 Page seeded by OCA on Fri May 2 18:38:08 2008

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