1hak

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1hak.gif|left|200px]]
[[Image:1hak.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1hak |SIZE=350|CAPTION= <scene name='initialview01'>1hak</scene>, resolution 3.0&Aring;
+
The line below this paragraph, containing "STRUCTURE_1hak", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=K21:4-[3-{1-(4-BENZYL)PIPERODINYL}PROPIONYL]-7-METHOXY-2,3,4,5-TERTRAHYDRO-1,4-BENZOTHIAZEPINE'>K21</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= CDNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1hak| PDB=1hak | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hak OCA], [http://www.ebi.ac.uk/pdbsum/1hak PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hak RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF RECOMBINANT HUMAN PLACENTAL ANNEXIN V COMPLEXED WITH K-201 AS A CALCIUM CHANNEL ACTIVITY INHIBITOR'''
'''CRYSTAL STRUCTURE OF RECOMBINANT HUMAN PLACENTAL ANNEXIN V COMPLEXED WITH K-201 AS A CALCIUM CHANNEL ACTIVITY INHIBITOR'''
Line 29: Line 26:
[[Category: Miyano, M.]]
[[Category: Miyano, M.]]
[[Category: 35kda calelectrin]]
[[Category: 35kda calelectrin]]
-
[[Category: annexin v]]
+
[[Category: Annexin v]]
-
[[Category: calcium/phospholipid-binding]]
+
[[Category: Calcium/phospholipid-binding]]
-
[[Category: endonexin ii]]
+
[[Category: Endonexin ii]]
-
[[Category: inhibitor of blood coagulation]]
+
[[Category: Inhibitor of blood coagulation]]
-
[[Category: lipocortin v]]
+
[[Category: Lipocortin v]]
-
[[Category: placenta anticoagulant protein-i]]
+
[[Category: Placenta anticoagulant protein-i]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:38:35 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:01:09 2008''
+

Revision as of 15:38, 2 May 2008

Image:1hak.gif

Template:STRUCTURE 1hak

CRYSTAL STRUCTURE OF RECOMBINANT HUMAN PLACENTAL ANNEXIN V COMPLEXED WITH K-201 AS A CALCIUM CHANNEL ACTIVITY INHIBITOR


Overview

The crystal structure of recombinant human annexin V complexed with K-201, an inhibitor of the calcium ion channel activity of annexin V, was solved at 3.0 A by molecular replacement including the apo and high-calcium forms. K-201 was bound at the hinge region cavity formed by the N-terminal strand and domains II, III and IV, at the side opposite the calcium and membrane-binding surface, in an L-shaped conformation. Based on the complex and other annexin structures, K-201 is proposed to restrain the hinge movement of annexin V in an allosteric manner, resulting in the inhibition of calcium movement across the annexin V molecule.

About this Structure

1HAK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of annexin V with its ligand K-201 as a calcium channel activity inhibitor., Kaneko N, Ago H, Matsuda R, Inagaki E, Miyano M, J Mol Biol. 1997 Nov 21;274(1):16-20. PMID:9398511 Page seeded by OCA on Fri May 2 18:38:35 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1hak"
Personal tools