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6x7r
From Proteopedia
(Difference between revisions)
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==E. coli beta-ketoacyl-[acyl carrier protein] synthase III (FabH) in complex with oxa(dethia)-coenzyme A== | ==E. coli beta-ketoacyl-[acyl carrier protein] synthase III (FabH) in complex with oxa(dethia)-coenzyme A== | ||
| - | <StructureSection load='6x7r' size='340' side='right'caption='[[6x7r]]' scene=''> | + | <StructureSection load='6x7r' size='340' side='right'caption='[[6x7r]], [[Resolution|resolution]] 1.35Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X7R FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6x7r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecodh Ecodh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X7R FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x7r OCA], [https://pdbe.org/6x7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x7r RCSB], [https://www.ebi.ac.uk/pdbsum/6x7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x7r ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UT7:oxa(dethia)-CoA'>UT7</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fabH, b1091, JW1077 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=316385 ECODH])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_III Beta-ketoacyl-[acyl-carrier-protein] synthase III], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.180 2.3.1.180] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x7r OCA], [https://pdbe.org/6x7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x7r RCSB], [https://www.ebi.ac.uk/pdbsum/6x7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x7r ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/FABH_ECOLI FABH_ECOLI]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for acetyl-CoA. Its substrate specificity determines the biosynthesis of straight-chain of fatty acids instead of branched-chain.[HAMAP-Rule:MF_01815] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Ecodh]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Benjamin | + | [[Category: Benjamin, A B]] |
| - | [[Category: Ling J]] | + | [[Category: Ling, J]] |
| - | [[Category: Lohman | + | [[Category: Lohman, J R]] |
| - | [[Category: Nice | + | [[Category: Nice, J N]] |
| - | [[Category: Stunkard | + | [[Category: Stunkard, L M]] |
| + | [[Category: Ketoacyl synthase]] | ||
| + | [[Category: Substrate analog]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 05:14, 15 June 2022
E. coli beta-ketoacyl-[acyl carrier protein] synthase III (FabH) in complex with oxa(dethia)-coenzyme A
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