3qz2
From Proteopedia
(Difference between revisions)
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==The structure of cysteine-free human insulin degrading enzyme== | ==The structure of cysteine-free human insulin degrading enzyme== | ||
| - | <StructureSection load='3qz2' size='340' side='right' caption='[[3qz2]], [[Resolution|resolution]] 3.20Å' scene=''> | + | <StructureSection load='3qz2' size='340' side='right'caption='[[3qz2]], [[Resolution|resolution]] 3.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3qz2]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3qz2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QZ2 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qz2 OCA], [https://pdbe.org/3qz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qz2 RCSB], [https://www.ebi.ac.uk/pdbsum/3qz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qz2 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
| - | *[[Insulin- | + | *[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Human]] | [[Category: Human]] | ||
[[Category: Insulysin]] | [[Category: Insulysin]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Guo, Q]] | [[Category: Guo, Q]] | ||
[[Category: Tang, W J]] | [[Category: Tang, W J]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Insulin degrading enzyme]] | [[Category: Insulin degrading enzyme]] | ||
Revision as of 05:42, 15 June 2022
The structure of cysteine-free human insulin degrading enzyme
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