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3r5k
From Proteopedia
(Difference between revisions)
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==A designed redox-controlled caspase-7== | ==A designed redox-controlled caspase-7== | ||
| - | <StructureSection load='3r5k' size='340' side='right' caption='[[3r5k]], [[Resolution|resolution]] 2.86Å' scene=''> | + | <StructureSection load='3r5k' size='340' side='right'caption='[[3r5k]], [[Resolution|resolution]] 2.86Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3r5k]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3r5k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R5K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R5K FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1f1j|1f1j]], [[1i4o|1i4o]], [[1k86|1k86]], [[1k88|1k88]], [[1gqf|1gqf]], [[1kmc|1kmc]], [[1i51|1i51]], [[1shj|1shj]], [[1shl|1shl]], [[2ql5|2ql5]], [[2ql7|2ql7]], [[2ql9|2ql9]], [[2qlb|2qlb]], [[2qlf|2qlf]], [[2qlj|2qlj]], [[3edr|3edr]], [[3h1p|3h1p]], [[3ibc|3ibc]], [[3ibf|3ibf]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1f1j|1f1j]], [[1i4o|1i4o]], [[1k86|1k86]], [[1k88|1k88]], [[1gqf|1gqf]], [[1kmc|1kmc]], [[1i51|1i51]], [[1shj|1shj]], [[1shl|1shl]], [[2ql5|2ql5]], [[2ql7|2ql7]], [[2ql9|2ql9]], [[2qlb|2qlb]], [[2qlf|2qlf]], [[2qlj|2qlj]], [[3edr|3edr]], [[3h1p|3h1p]], [[3ibc|3ibc]], [[3ibf|3ibf]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP7, MCH3 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP7, MCH3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r5k OCA], [https://pdbe.org/3r5k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r5k RCSB], [https://www.ebi.ac.uk/pdbsum/3r5k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r5k ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
| - | *[[Caspase|Caspase]] | + | *[[Caspase 3D structures|Caspase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Caspase-7]] | [[Category: Caspase-7]] | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Hardy, J A]] | [[Category: Hardy, J A]] | ||
[[Category: Witkowski, W A]] | [[Category: Witkowski, W A]] | ||
Revision as of 05:49, 15 June 2022
A designed redox-controlled caspase-7
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