Journal:Acta Cryst F:S2053230X21012632

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FabG2(NADH-dependent) in complex with NADH, wheat] and PDB entry [[6ixm]] (ketone reductase ChKRED20 from the genome of ''Chryseobacterium'', aquamarine). The cofactor, NADH (magenta) and substrate, (4R)-2-methylpentane-2,4-diol (royalblue), are from PDB entry [[1iy8]]. Structures were superposed with ''PyMOL''. Uniquely, the <scene name='89/899477/Cv/4'>cofactor binding cavity</scene> of ''Px''SDR is not well conserved and differs from other SDRs. The cofactor-binding cavity is labeled in magenta. ''Px''SDR has an additional seven-amino acids that form an <scene name='89/899477/Cv/5'>additional unique loop</scene> within the co-factor binding cavity. Further studies are required to determine how these differences affect the enzymatic functions of the SDR. This project is an educational collaboration between the Seattle Structural Genomics Center for Infectious Disease (SSGCID) and Hampton University where undergraduate students are engaged in structure-function analysis and publication of structures solved by the SSGCID.
FabG2(NADH-dependent) in complex with NADH, wheat] and PDB entry [[6ixm]] (ketone reductase ChKRED20 from the genome of ''Chryseobacterium'', aquamarine). The cofactor, NADH (magenta) and substrate, (4R)-2-methylpentane-2,4-diol (royalblue), are from PDB entry [[1iy8]]. Structures were superposed with ''PyMOL''. Uniquely, the <scene name='89/899477/Cv/4'>cofactor binding cavity</scene> of ''Px''SDR is not well conserved and differs from other SDRs. The cofactor-binding cavity is labeled in magenta. ''Px''SDR has an additional seven-amino acids that form an <scene name='89/899477/Cv/5'>additional unique loop</scene> within the co-factor binding cavity. Further studies are required to determine how these differences affect the enzymatic functions of the SDR. This project is an educational collaboration between the Seattle Structural Genomics Center for Infectious Disease (SSGCID) and Hampton University where undergraduate students are engaged in structure-function analysis and publication of structures solved by the SSGCID.
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PDB reference: putative short-chain reductase, [[5jc8]].
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'''PDB reference:''' putative short-chain reductase, [[5jc8]].
<b>References</b><br>
<b>References</b><br>

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