Journal:IUCrJ:S2052252520001840

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Interestingly, the rigid <scene name='83/835837/Cv/10'>interface 1</scene> included a <scene name='83/835837/Cv/11'>D231(MICU1)-R352(MICU2) salt bridge</scene>, and D231 is a highly conserved residue for Ca<sup>2+</sup> coordination in MICU1 EF-hand 1. Thus, MICU1 EF-hand 1 can bind calcium when the salt bridge dissociates. The tight interaction in apo state of MICU1-MICU2 might hinder the conformational changes required for the Ca<sup>2+</sup> binding, resulting in a lower Ca<sup>2+</sup> binding affinity in the MICU1-MICU2 heterodimer as compared to that of MICU1 homodimer.
Interestingly, the rigid <scene name='83/835837/Cv/10'>interface 1</scene> included a <scene name='83/835837/Cv/11'>D231(MICU1)-R352(MICU2) salt bridge</scene>, and D231 is a highly conserved residue for Ca<sup>2+</sup> coordination in MICU1 EF-hand 1. Thus, MICU1 EF-hand 1 can bind calcium when the salt bridge dissociates. The tight interaction in apo state of MICU1-MICU2 might hinder the conformational changes required for the Ca<sup>2+</sup> binding, resulting in a lower Ca<sup>2+</sup> binding affinity in the MICU1-MICU2 heterodimer as compared to that of MICU1 homodimer.
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PDB reference: crystal structure of the mitochondrial calcium uptake 1 and 2 heterodimer (MICU1–MICU2 heterodimer) in an apo state, [[6le5]].
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'''PDB reference:''' crystal structure of the mitochondrial calcium uptake 1 and 2 heterodimer (MICU1–MICU2 heterodimer) in an apo state, [[6le5]].
<b>References</b><br>
<b>References</b><br>

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