1hdr

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[[Image:1hdr.gif|left|200px]]
[[Image:1hdr.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1hdr |SIZE=350|CAPTION= <scene name='initialview01'>1hdr</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1hdr", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/6,7-dihydropteridine_reductase 6,7-dihydropteridine reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.34 1.5.1.34] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= CDNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1hdr| PDB=1hdr | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hdr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hdr OCA], [http://www.ebi.ac.uk/pdbsum/1hdr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hdr RCSB]</span>
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}}
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'''THE CRYSTALLOGRAPHIC STRUCTURE OF A HUMAN DIHYDROPTERIDINE REDUCTASE NADH BINARY COMPLEX EXPRESSED IN ESCHERICHIA COLI BY A CDNA CONSTRUCTED FROM ITS RAT HOMOLOGUE'''
'''THE CRYSTALLOGRAPHIC STRUCTURE OF A HUMAN DIHYDROPTERIDINE REDUCTASE NADH BINARY COMPLEX EXPRESSED IN ESCHERICHIA COLI BY A CDNA CONSTRUCTED FROM ITS RAT HOMOLOGUE'''
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[[Category: Whiteley, J M.]]
[[Category: Whiteley, J M.]]
[[Category: Xuong, N H.]]
[[Category: Xuong, N H.]]
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[[Category: oxidoreductase(acting on nadh)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:44:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:03:03 2008''
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Revision as of 15:44, 2 May 2008

Image:1hdr.gif

Template:STRUCTURE 1hdr

THE CRYSTALLOGRAPHIC STRUCTURE OF A HUMAN DIHYDROPTERIDINE REDUCTASE NADH BINARY COMPLEX EXPRESSED IN ESCHERICHIA COLI BY A CDNA CONSTRUCTED FROM ITS RAT HOMOLOGUE


Overview

A human dihydropteridine reductase (EC 1.6.99.10) has been created from a rat cDNA clone by a single five-oligonucleotide mutagenesis reaction and expressed in good yield in Escherichia coli. The enzyme has been purified to homogeneity, and kinetic identity to the naturally occurring enzyme has been proven. Crystallization has also been achieved, and the crystal structure was solved using 2.5 A data that was refined to an R value of 16.9%. The structure described in this report represents the first complete structural characterization of this important human enzyme.

About this Structure

1HDR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from its rat homologue., Su Y, Varughese KI, Xuong NH, Bray TL, Roche DJ, Whiteley JM, J Biol Chem. 1993 Dec 25;268(36):26836-41. PMID:8262916 Page seeded by OCA on Fri May 2 18:44:30 2008

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