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1hei
From Proteopedia
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[[Image:1hei.gif|left|200px]] | [[Image:1hei.gif|left|200px]] | ||
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'''STRUCTURE OF THE HEPATITIS C VIRUS RNA HELICASE DOMAIN''' | '''STRUCTURE OF THE HEPATITIS C VIRUS RNA HELICASE DOMAIN''' | ||
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==Reference== | ==Reference== | ||
Structure of the hepatitis C virus RNA helicase domain., Yao N, Hesson T, Cable M, Hong Z, Kwong AD, Le HV, Weber PC, Nat Struct Biol. 1997 Jun;4(6):463-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9187654 9187654] | Structure of the hepatitis C virus RNA helicase domain., Yao N, Hesson T, Cable M, Hong Z, Kwong AD, Le HV, Weber PC, Nat Struct Biol. 1997 Jun;4(6):463-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9187654 9187654] | ||
| - | [[Category: Hepatitis c virus genotype 1a (isolate 1)]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Weber, P.]] | [[Category: Weber, P.]] | ||
[[Category: Yao, N.]] | [[Category: Yao, N.]] | ||
| - | [[Category: | + | [[Category: Atpase]] |
| - | [[Category: | + | [[Category: Hcv]] |
| - | [[Category: | + | [[Category: Helicase]] |
| - | [[Category: | + | [[Category: Hepatitis]] |
| - | [[Category: | + | [[Category: Ntpase]] |
| - | [[Category: | + | [[Category: Rna]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:46:06 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 15:46, 2 May 2008
STRUCTURE OF THE HEPATITIS C VIRUS RNA HELICASE DOMAIN
Overview
Helicases are nucleotide triphosphate (NTP)-dependent enzymes responsible for unwinding duplex DNA and RNA during genomic replication. The 2.1 A resolution structure of the HCV helicase from the positive-stranded RNA hepatitis C virus reveals a molecule with distinct NTPase and RNA binding domains. The structure supports a mechanism of helicase activity involving initial recognition of the requisite 3' single-stranded region on the nucleic acid substrate by a conserved arginine-rich sequence on the RNA binding domain. Comparison of crystallographically independent molecules shows that rotation of the RNA binding domain involves conformational changes within a conserved TATPP sequence and untwisting of an extended antiparallel beta-sheet. Location of the TATPP sequence at the end of an NTPase domain beta-strand structurally homologous to the 'switch region' of many NTP-dependent enzymes offers the possibility that domain rotation is coupled to NTP hydrolysis in the helicase catalytic cycle.
About this Structure
1HEI is a Single protein structure of sequence from Hepatitis c virus genotype 1a (isolate 1). Full crystallographic information is available from OCA.
Reference
Structure of the hepatitis C virus RNA helicase domain., Yao N, Hesson T, Cable M, Hong Z, Kwong AD, Le HV, Weber PC, Nat Struct Biol. 1997 Jun;4(6):463-7. PMID:9187654 Page seeded by OCA on Fri May 2 18:46:06 2008
Categories: Single protein | Weber, P. | Yao, N. | Atpase | Hcv | Helicase | Hepatitis | Ntpase | Rna
