1het

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[[Image:1het.gif|left|200px]]
[[Image:1het.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1het |SIZE=350|CAPTION= <scene name='initialview01'>1het</scene>, resolution 1.15&Aring;
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The line below this paragraph, containing "STRUCTURE_1het", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC3:Zn+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Zn+Binding+Site+For+Chain+B'>AC4</scene>, <scene name='pdbsite=NAA:Chain+A+Nucleotide+Binding+Site'>NAA</scene>, <scene name='pdbsite=NAB:Chain+B+Nucleotide+Binding+Site'>NAB</scene>, <scene name='pdbsite=OHA:Active+Site+w.+Zn+Bound+Hydroxide+For+Chain+A'>OHA</scene> and <scene name='pdbsite=OHB:Active+Site+w.+Zn+Bound+Hydroxide+For+Chain+B'>OHB</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase Alcohol dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.1 1.1.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1het| PDB=1het | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1het FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1het OCA], [http://www.ebi.ac.uk/pdbsum/1het PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1het RCSB]</span>
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}}
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'''ATOMIC X-RAY STRUCTURE OF LIVER ALCOHOL DEHYDROGENASE CONTAINING A HYDROXIDE ADDUCT TO NADH'''
'''ATOMIC X-RAY STRUCTURE OF LIVER ALCOHOL DEHYDROGENASE CONTAINING A HYDROXIDE ADDUCT TO NADH'''
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[[Category: Merli, A.]]
[[Category: Merli, A.]]
[[Category: Morris, R J.]]
[[Category: Morris, R J.]]
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[[Category: oxidoreductase(nad(a)-choh(d))]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:46:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:03:43 2008''
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Revision as of 15:46, 2 May 2008

Image:1het.gif

Template:STRUCTURE 1het

ATOMIC X-RAY STRUCTURE OF LIVER ALCOHOL DEHYDROGENASE CONTAINING A HYDROXIDE ADDUCT TO NADH


Overview

Atomic (1 A) resolution x-ray structures of horse liver alcohol dehydrogenase in complex with NADH revealed the formation of an adduct in the active site between a metal-bound water and NADH. Furthermore, a pronounced distortion of the pyridine ring of NADH was observed. A series of quantum chemical calculations on the water-nicotinamide adduct showed that the puckering of the pyridine ring in the crystal structures can only be reproduced when the water is considered a hydroxide ion. These observations provide fundamental insight into the enzymatic activation of NADH for hydride transfer.

About this Structure

1HET is a Single protein structure of sequence from Equus caballus. Full crystallographic information is available from OCA.

Reference

On the enzymatic activation of NADH., Meijers R, Morris RJ, Adolph HW, Merli A, Lamzin VS, Cedergren-Zeppezauer ES, J Biol Chem. 2001 Mar 23;276(12):9316-21. Epub 2000 Dec 28. PMID:11134046 Page seeded by OCA on Fri May 2 18:46:39 2008

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