1hig

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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hig OCA], [http://www.ebi.ac.uk/pdbsum/1hig PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hig RCSB]</span>
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'''THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN INTERFERON-GAMMA.'''
'''THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN INTERFERON-GAMMA.'''
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[[Category: Trotta, P P.]]
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[[Category: Vijay-Kumar, S.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:52:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:05:28 2008''
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Revision as of 15:52, 2 May 2008

Image:1hig.gif

Template:STRUCTURE 1hig

THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN INTERFERON-GAMMA.


Overview

The x-ray crystal structure of recombinant human interferon-gamma has been determined with the use of multiple-isomorphous-replacement techniques. Interferon-gamma, which is dimeric in solution, crystallizes with two dimers related by a noncrystallographic twofold axis in the asymmetric unit. The protein is primarily alpha helical, with six helices in each subunit that comprise approximately 62 percent of the structure; there is no beta sheet. The dimeric structure of human interferon-gamma is stabilized by the intertwining of helices across the subunit interface with multiple intersubunit interactions.

About this Structure

1HIG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of recombinant human interferon-gamma., Ealick SE, Cook WJ, Vijay-Kumar S, Carson M, Nagabhushan TL, Trotta PP, Bugg CE, Science. 1991 May 3;252(5006):698-702. PMID:1902591 Page seeded by OCA on Fri May 2 18:52:40 2008

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