3rm1
From Proteopedia
(Difference between revisions)
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==1.24 Angstrom X-ray structure of bovine TRTK12-Ca(2+)-S100B D63N== | ==1.24 Angstrom X-ray structure of bovine TRTK12-Ca(2+)-S100B D63N== | ||
| - | <StructureSection load='3rm1' size='340' side='right' caption='[[3rm1]], [[Resolution|resolution]] 1.24Å' scene=''> | + | <StructureSection load='3rm1' size='340' side='right'caption='[[3rm1]], [[Resolution|resolution]] 1.24Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3rm1]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3rm1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RM1 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rlz|3rlz]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3rlz|3rlz]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S100B ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S100B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rm1 OCA], [https://pdbe.org/3rm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rm1 RCSB], [https://www.ebi.ac.uk/pdbsum/3rm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rm1 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/S100B_BOVIN S100B_BOVIN]] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).<ref>PMID:14661952</ref> [[https://www.uniprot.org/uniprot/CAZA2_BOVIN CAZA2_BOVIN]] F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). |
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| + | ==See Also== | ||
| + | *[[S100 proteins 3D structures|S100 proteins 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Bovin]] | [[Category: Bovin]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Liriano, M A]] | [[Category: Liriano, M A]] | ||
[[Category: Weber, D J]] | [[Category: Weber, D J]] | ||
Revision as of 10:16, 22 June 2022
1.24 Angstrom X-ray structure of bovine TRTK12-Ca(2+)-S100B D63N
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