This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3rp1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
==Crystal structure of Human LAIR-1 in C2 space group==
==Crystal structure of Human LAIR-1 in C2 space group==
-
<StructureSection load='3rp1' size='340' side='right' caption='[[3rp1]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+
<StructureSection load='3rp1' size='340' side='right'caption='[[3rp1]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3rp1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RP1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RP1 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3rp1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RP1 FirstGlance]. <br>
-
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD305, LAIR-1, LAIR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD305, LAIR-1, LAIR1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rp1 OCA], [http://pdbe.org/3rp1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rp1 RCSB], [http://www.ebi.ac.uk/pdbsum/3rp1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rp1 ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rp1 OCA], [https://pdbe.org/3rp1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rp1 RCSB], [https://www.ebi.ac.uk/pdbsum/3rp1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rp1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/LAIR1_HUMAN LAIR1_HUMAN]] Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.<ref>PMID:9285412</ref> <ref>PMID:10229813</ref> <ref>PMID:10764762</ref> <ref>PMID:9692876</ref> <ref>PMID:11069054</ref> <ref>PMID:11160222</ref> <ref>PMID:12072189</ref> <ref>PMID:15939744</ref> <ref>PMID:15950745</ref> <ref>PMID:16380958</ref>
+
[[https://www.uniprot.org/uniprot/LAIR1_HUMAN LAIR1_HUMAN]] Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.<ref>PMID:9285412</ref> <ref>PMID:10229813</ref> <ref>PMID:10764762</ref> <ref>PMID:9692876</ref> <ref>PMID:11069054</ref> <ref>PMID:11160222</ref> <ref>PMID:12072189</ref> <ref>PMID:15939744</ref> <ref>PMID:15950745</ref> <ref>PMID:16380958</ref>
==See Also==
==See Also==
Line 17: Line 17:
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
 +
[[Category: Large Structures]]
[[Category: Almo, S C]]
[[Category: Almo, S C]]
[[Category: Bonanno, J]]
[[Category: Bonanno, J]]

Revision as of 10:20, 22 June 2022

Crystal structure of Human LAIR-1 in C2 space group

PDB ID 3rp1

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3rp1"
Personal tools