1hiw
From Proteopedia
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'''TRIMERIC HIV-1 MATRIX PROTEIN''' | '''TRIMERIC HIV-1 MATRIX PROTEIN''' | ||
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[[Category: Sundquist, W I.]] | [[Category: Sundquist, W I.]] | ||
[[Category: Worthylake, D.]] | [[Category: Worthylake, D.]] | ||
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| - | [[Category: | + | [[Category: Hiv-1 ma]] |
| - | [[Category: | + | [[Category: Matrix protein]] |
| - | [[Category: | + | [[Category: P17]] |
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Revision as of 15:53, 2 May 2008
TRIMERIC HIV-1 MATRIX PROTEIN
Overview
The human immunodeficiency virus type 1 (HIV-1) matrix protein forms a structural shell associated with the inner viral membrane and performs other essential functions throughout the viral life cycle. The crystal structure of the HIV-1 matrix protein, determined at 2.3 angstrom resolution, reveals that individual matrix molecules are composed of five major helices capped by a three-stranded mixed beta-sheet. Unexpectedly, the protein assembles into a trimer in three different crystal lattices, burying 1880 angstrom2 of accessible surface area at the trimer interfaces. Trimerization appears to create a large, bipartite membrane binding surface in which exposed basic residues could cooperate with the N-terminal myristoyl groups to anchor the protein on the acidic inner membrane of the virus.
About this Structure
1HIW is a Single protein structure of sequence from Human immunodeficiency virus. Full crystallographic information is available from OCA.
Reference
Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: implications for membrane association and assembly., Hill CP, Worthylake D, Bancroft DP, Christensen AM, Sundquist WI, Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3099-104. PMID:8610175 Page seeded by OCA on Fri May 2 18:53:18 2008
