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3s3x
From Proteopedia
(Difference between revisions)
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==Structure of chicken acid-sensing ion channel 1 AT 3.0 A resolution in complex with psalmotoxin== | ==Structure of chicken acid-sensing ion channel 1 AT 3.0 A resolution in complex with psalmotoxin== | ||
| - | <StructureSection load='3s3x' size='340' side='right' caption='[[3s3x]], [[Resolution|resolution]] 2.99Å' scene=''> | + | <StructureSection load='3s3x' size='340' side='right'caption='[[3s3x]], [[Resolution|resolution]] 2.99Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3s3x]] is a 6 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3s3x]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S3X FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3s3w|3s3w]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3s3w|3s3w]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACCN2, ASIC1 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACCN2, ASIC1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s3x OCA], [https://pdbe.org/3s3x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s3x RCSB], [https://www.ebi.ac.uk/pdbsum/3s3x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s3x ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ASIC1_CHICK ASIC1_CHICK]] Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride (By similarity).<ref>PMID:16002453</ref> [[https://www.uniprot.org/uniprot/TXP1_PSACA TXP1_PSACA]] Potently and selectively blocks the acid-sensing ion channel ASIC1a/ACCN2. The blockade is rapid and reversible. Psalmotoxin 1 loses its capacity to block ASIC1a/ACCN2 as soon as this subunit is associated with another member of the family (ASIC2a/ACCN1 or ASIC3/ACCN3). The toxin can distinguish between the two ASIC1/ACCN2 splice variants ASIC1a/ACCN2 and ASIC1b/ACCN2.<ref>PMID:10829030</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 3s3x" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 3s3x" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Ion channels 3D structures|Ion channels 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Chick]] | [[Category: Chick]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Benz, J]] | [[Category: Benz, J]] | ||
[[Category: Dawson, R J.P]] | [[Category: Dawson, R J.P]] | ||
Revision as of 10:37, 22 June 2022
Structure of chicken acid-sensing ion channel 1 AT 3.0 A resolution in complex with psalmotoxin
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Categories: Chick | Large Structures | Benz, J | Dawson, R J.P | Hennig, M | Huber, S | Huegin, D | Joseph, C | Pflimlin, P | Rudolph, M G | Ruf, A | Schmid, G | Stohler, P | Tetaz, T | Trube, G | Acid-sensing | Cell membrane | Cysteine knot | Glycoprotein | Ion channel | Ion transport | Membrane | Membrane protein | Sodium channel | Sodium transport | Toxin | Transmembrane | Transport | Transport protein
