1hj3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1hj3.jpg|left|200px]]
[[Image:1hj3.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1hj3 |SIZE=350|CAPTION= <scene name='initialview01'>1hj3</scene>, resolution 1.6&Aring;
+
The line below this paragraph, containing "STRUCTURE_1hj3", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=C1A:The+C+Hem+Is+The+Point+Of+Electron+Entry'>C1A</scene>, <scene name='pdbsite=C1B:The+C+Hem+Is+The+Point+Of+Electron+Entry'>C1B</scene>, <scene name='pdbsite=D1A:The+D+Hem+Is+The+Site+Of+Catalytic+Activity'>D1A</scene> and <scene name='pdbsite=D1B:The+D+Hem+Is+The+Site+Of+Catalytic+Activity'>D1B</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=DHE:HEME+D'>DHE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1hj3| PDB=1hj3 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hj3 OCA], [http://www.ebi.ac.uk/pdbsum/1hj3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hj3 RCSB]</span>
+
-
}}
+
'''CYTOCHROME CD1 NITRITE REDUCTASE, DIOXYGEN COMPLEX'''
'''CYTOCHROME CD1 NITRITE REDUCTASE, DIOXYGEN COMPLEX'''
Line 27: Line 24:
[[Category: Hajdu, J.]]
[[Category: Hajdu, J.]]
[[Category: Sjogren, T.]]
[[Category: Sjogren, T.]]
-
[[Category: enzyme]]
+
[[Category: Enzyme]]
-
[[Category: nitrite reductase]]
+
[[Category: Nitrite reductase]]
-
[[Category: oxidoreductase]]
+
[[Category: Oxidoreductase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:53:41 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:05:56 2008''
+

Revision as of 15:53, 2 May 2008

Image:1hj3.jpg

Template:STRUCTURE 1hj3

CYTOCHROME CD1 NITRITE REDUCTASE, DIOXYGEN COMPLEX


Overview

Reduction of dioxygen to water is a key process in aerobic life, but atomic details of this reaction have been elusive because of difficulties in observing active oxygen intermediates by crystallography. Cytochrome cd(1) is a bifunctional enzyme, capable of catalyzing the one-electron reduction of nitrite to nitric oxide, and the four-electron reduction of dioxygen to water. The latter is a cytochrome oxidase reaction. Here we describe the structure of an active dioxygen species in the enzyme captured by cryo-trapping. The productive binding mode of dioxygen in the active site is very similar to that of nitrite and suggests that the catalytic mechanisms of oxygen reduction and nitrite reduction are closely related. This finding has implications to the understanding of the evolution of oxygen-reducing enzymes. Comparison of the dioxygen complex to complexes of cytochrome cd(1) with stable diatomic ligands shows that nitric oxide and cyanide bind in a similar bent conformation to the iron as dioxygen whereas carbon monoxide forms a linear complex. The significance of these differences is discussed.

About this Structure

1HJ3 is a Single protein structure of sequence from Paracoccus pantotrophus. Full crystallographic information is available from OCA.

Reference

Structure of the bound dioxygen species in the cytochrome oxidase reaction of cytochrome cd1 nitrite reductase., Sjogren T, Hajdu J, J Biol Chem. 2001 Apr 20;276(16):13072-6. Epub 2001 Jan 26. PMID:11278884 Page seeded by OCA on Fri May 2 18:53:41 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1hj3"
Personal tools