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3s8e

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==Phosphorylation regulates assembly of the caspase-6 substrate-binding groove==
==Phosphorylation regulates assembly of the caspase-6 substrate-binding groove==
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<StructureSection load='3s8e' size='340' side='right' caption='[[3s8e]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
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<StructureSection load='3s8e' size='340' side='right'caption='[[3s8e]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3s8e]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S8E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3s8e]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S8E FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wdp|2wdp]], [[3nkf|3nkf]], [[3nr2|3nr2]], [[3od5|3od5]], [[3k7e|3k7e]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wdp|2wdp]], [[3nkf|3nkf]], [[3nr2|3nr2]], [[3od5|3od5]], [[3k7e|3k7e]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP6, MCH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP6, MCH2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-6 Caspase-6], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.59 3.4.22.59] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Caspase-6 Caspase-6], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.59 3.4.22.59] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8e OCA], [http://pdbe.org/3s8e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3s8e RCSB], [http://www.ebi.ac.uk/pdbsum/3s8e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3s8e ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s8e OCA], [https://pdbe.org/3s8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s8e RCSB], [https://www.ebi.ac.uk/pdbsum/3s8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s8e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
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[[https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Caspase|Caspase]]
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*[[Caspase 3D structures|Caspase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Caspase-6]]
[[Category: Caspase-6]]
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Hardy, J A]]
[[Category: Hardy, J A]]
[[Category: Velazquez-Delgado, E M]]
[[Category: Velazquez-Delgado, E M]]
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[[Category: Alzheimers']]
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[[Category: Alzheimerss']]
[[Category: Apoptosis]]
[[Category: Apoptosis]]
[[Category: Cancer]]
[[Category: Cancer]]
[[Category: Caspase]]
[[Category: Caspase]]
[[Category: Cytosol]]
[[Category: Cytosol]]
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[[Category: Huntingtons']]
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[[Category: Huntingtonss']]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Phosphomimetic]]
[[Category: Phosphomimetic]]
[[Category: Protease]]
[[Category: Protease]]
[[Category: Zymogen]]
[[Category: Zymogen]]

Revision as of 10:42, 22 June 2022

Phosphorylation regulates assembly of the caspase-6 substrate-binding groove

PDB ID 3s8e

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