Siroheme synthase

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(New page: <StructureSection load='6p5z' size='340' side='right' caption='Salmonella typhimurium siroheme synthase complex withCo-sirohydrochlorin, SAH and Cl- ion (PDB code 6p5z) ' scene=''> Th...)
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<StructureSection load='6p5z' size='340' side='right' caption='Salmonella typhimurium siroheme synthase complex withCo-sirohydrochlorin, SAH and Cl- ion (PDB code [[6p5z]]) ' scene=''>
<StructureSection load='6p5z' size='340' side='right' caption='Salmonella typhimurium siroheme synthase complex withCo-sirohydrochlorin, SAH and Cl- ion (PDB code [[6p5z]]) ' scene=''>
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This is a default text for your page '''Siroheme synthase'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
 
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
 
== Function ==
== Function ==
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== Disease ==
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'''Siroheme synthase''' (CysG) catalyzes the reduction of sulfite to sulfide or nitrite to ammonia<ref>PMId:32054833</ref>. CysG substrate is a tetrapyrrole.
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== Relevance ==
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== Structural highlights ==
== Structural highlights ==
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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The tetrapyrrole in siroheme is heavily negatively charged because of the 8 acetyl and propionyl carboxylates at the corners of the siroheme and it interacts with residues of subunit #1 and subunit #2. Seven of these residues are positively charged Arg and Lys residues.
</StructureSection>
</StructureSection>
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==Siroheme synthase 3D structures==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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**[[1pjq]] – StCysG + SAH – ''Salmonella typhimurium''<BR />
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**[[1pjt]], [[6p7c]], [[6p7d]], [[6pqz]], [[6pr0]], [[6pr1]], [[6pr2]], [[6pr3]], [[6pr4]], [[6ulu]] – StCysG (mutant) + SAH <BR />
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**[[6p5z]] – StCysG + SAH + Co-sirohydrochlorin <BR />
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**[[1pjs]] – StCysG + SAH + NAD <BR />
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**[[6p5x]] – StCysG (mutant) + SAH + substrate<BR />
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**[[6veb]] – StCysG (mutant) + SAH + NAD + pecorrin<BR />
== References ==
== References ==
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<references/>
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[[Category:Topic Page]]

Revision as of 10:32, 28 June 2022

Salmonella typhimurium siroheme synthase complex withCo-sirohydrochlorin, SAH and Cl- ion (PDB code 6p5z)

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Siroheme synthase 3D structures

Updated on 28-June-2022

References

  1. ↑ Pennington JM, Kemp M, McGarry L, Chen Y, Stroupe ME. Siroheme synthase orients substrates for dehydrogenase and chelatase activities in a common active site. Nat Commun. 2020 Feb 13;11(1):864. doi: 10.1038/s41467-020-14722-1. PMID:32054833 doi:http://dx.doi.org/10.1038/s41467-020-14722-1

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

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