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Siroheme synthase
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='6p5z' size='340' side='right' caption='Salmonella typhimurium siroheme synthase complex withCo-sirohydrochlorin, SAH and Cl- ion (PDB code 6p5z) ' scene=''> Th...) |
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<StructureSection load='6p5z' size='340' side='right' caption='Salmonella typhimurium siroheme synthase complex withCo-sirohydrochlorin, SAH and Cl- ion (PDB code [[6p5z]]) ' scene=''> | <StructureSection load='6p5z' size='340' side='right' caption='Salmonella typhimurium siroheme synthase complex withCo-sirohydrochlorin, SAH and Cl- ion (PDB code [[6p5z]]) ' scene=''> | ||
| - | This is a default text for your page '''Siroheme synthase'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
| - | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
== Function == | == Function == | ||
| - | + | '''Siroheme synthase''' (CysG) catalyzes the reduction of sulfite to sulfide or nitrite to ammonia<ref>PMId:32054833</ref>. CysG substrate is a tetrapyrrole. | |
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== Structural highlights == | == Structural highlights == | ||
| - | + | The tetrapyrrole in siroheme is heavily negatively charged because of the 8 acetyl and propionyl carboxylates at the corners of the siroheme and it interacts with residues of subunit #1 and subunit #2. Seven of these residues are positively charged Arg and Lys residues. | |
</StructureSection> | </StructureSection> | ||
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| + | ==Siroheme synthase 3D structures== | ||
| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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| + | **[[1pjq]] – StCysG + SAH – ''Salmonella typhimurium''<BR /> | ||
| + | **[[1pjt]], [[6p7c]], [[6p7d]], [[6pqz]], [[6pr0]], [[6pr1]], [[6pr2]], [[6pr3]], [[6pr4]], [[6ulu]] – StCysG (mutant) + SAH <BR /> | ||
| + | **[[6p5z]] – StCysG + SAH + Co-sirohydrochlorin <BR /> | ||
| + | **[[1pjs]] – StCysG + SAH + NAD <BR /> | ||
| + | **[[6p5x]] – StCysG (mutant) + SAH + substrate<BR /> | ||
| + | **[[6veb]] – StCysG (mutant) + SAH + NAD + pecorrin<BR /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
Revision as of 10:32, 28 June 2022
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Siroheme synthase 3D structures
Updated on 28-June-2022
References
- ↑ Pennington JM, Kemp M, McGarry L, Chen Y, Stroupe ME. Siroheme synthase orients substrates for dehydrogenase and chelatase activities in a common active site. Nat Commun. 2020 Feb 13;11(1):864. doi: 10.1038/s41467-020-14722-1. PMID:32054833 doi:http://dx.doi.org/10.1038/s41467-020-14722-1
