1hjd
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1hjd.jpg|left|200px]] | [[Image:1hjd.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1hjd", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_1hjd| PDB=1hjd | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''MELANOMA INHIBITORY ACTIVITY (MIA) PROTEIN''' | '''MELANOMA INHIBITORY ACTIVITY (MIA) PROTEIN''' | ||
| Line 29: | Line 26: | ||
[[Category: Stoll, R.]] | [[Category: Stoll, R.]] | ||
[[Category: Voelter, W.]] | [[Category: Voelter, W.]] | ||
| - | [[Category: | + | [[Category: Growth factor]] |
| - | [[Category: | + | [[Category: Signal]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:54:22 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 15:54, 2 May 2008
MELANOMA INHIBITORY ACTIVITY (MIA) PROTEIN
Overview
Melanoma inhibitory activity (MIA) protein is a clinically valuable marker in patients with malignant melanoma, as enhanced values diagnose metastatic melanoma stages III and IV. Here we show that the recombinant human MIA adopts an SH3 domain-like fold in solution, with two perpendicular, antiparallel, three- and five-stranded beta-sheets. In contrast to known structures with the SH3 domain fold, MIA is a single-domain protein, and contains an additional antiparallel beta-sheet and two disulfide bonds. MIA is also the first extracellular protein found to have the SH3 domain-like fold. Furthermore, we show that MIA interacts with fibronectin and that the peptide ligands identified for MIA exhibit a matching sequence to type III human fibronectin repeats, especially to FN14, which is close to an integrin alpha4beta1 binding site. The present study, therefore, may explain the role of MIA in metastasis in vivo, and supports a model in which the binding of human MIA to type III repeats of fibronectin competes with integrin binding, thus detaching cells from the extracellular matrix.
About this Structure
1HJD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The extracellular human melanoma inhibitory activity (MIA) protein adopts an SH3 domain-like fold., Stoll R, Renner C, Zweckstetter M, Bruggert M, Ambrosius D, Palme S, Engh RA, Golob M, Breibach I, Buettner R, Voelter W, Holak TA, Bosserhoff AK, EMBO J. 2001 Feb 1;20(3):340-9. PMID:11157741 Page seeded by OCA on Fri May 2 18:54:22 2008
