This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1fin
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1fin" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fin, resolution 2.3Å" /> '''CYCLIN A-CYCLIN-DEPE...)
Next diff →
Revision as of 14:47, 12 November 2007
|
CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX
Overview
The crystal structure of the human cyclinA-cyclin-dependent kinase2, (CDK2)-ATP complex has been determined at 2.3 A resolution. CyclinA binds, to one side of CDK2's catalytic cleft, inducing large conformational, changes in its PSTAIRE helix and T-loop. These changes activate the kinase, by realigning active site residues and relieving the steric blockade at, the entrance of the catalytic cleft.
About this Structure
1FIN is a Protein complex structure of sequences from Homo sapiens with ATP as ligand. Full crystallographic information is available from OCA.
Reference
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex., Jeffrey PD, Russo AA, Polyak K, Gibbs E, Hurwitz J, Massague J, Pavletich NP, Nature. 1995 Jul 27;376(6538):313-20. PMID:7630397
Page seeded by OCA on Mon Nov 12 16:53:44 2007
