3sn2

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==Crystal structure analysis of iron regulatory protein 1 in complex with transferrin receptor IRE B RNA==
==Crystal structure analysis of iron regulatory protein 1 in complex with transferrin receptor IRE B RNA==
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<StructureSection load='3sn2' size='340' side='right' caption='[[3sn2]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
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<StructureSection load='3sn2' size='340' side='right'caption='[[3sn2]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3sn2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SN2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3sn2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SN2 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ipy|2ipy]], [[3snp|3snp]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ipy|2ipy]], [[3snp|3snp]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACO1, FRP, IREB1, IREBP, IRP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACO1, FRP, IREB1, IREBP, IRP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aconitate_hydratase Aconitate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.3 4.2.1.3] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aconitate_hydratase Aconitate hydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.3 4.2.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sn2 OCA], [http://pdbe.org/3sn2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3sn2 RCSB], [http://www.ebi.ac.uk/pdbsum/3sn2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3sn2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sn2 OCA], [https://pdbe.org/3sn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sn2 RCSB], [https://www.ebi.ac.uk/pdbsum/3sn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sn2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACOC_RABIT ACOC_RABIT]] Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding (By similarity). Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity).
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[[https://www.uniprot.org/uniprot/ACOC_RABIT ACOC_RABIT]] Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding (By similarity). Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3sn2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3sn2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aconitase 3D structures|Aconitase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Aconitate hydratase]]
[[Category: Aconitate hydratase]]
[[Category: European rabbit]]
[[Category: European rabbit]]
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[[Category: Large Structures]]
[[Category: Selezneva, A I]]
[[Category: Selezneva, A I]]
[[Category: Volz, K]]
[[Category: Volz, K]]

Revision as of 08:02, 29 June 2022

Crystal structure analysis of iron regulatory protein 1 in complex with transferrin receptor IRE B RNA

PDB ID 3sn2

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