Syntenin
From Proteopedia
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<StructureSection load='1ybo' size='340' side='right' caption='Human syntenin PDZ1+PDZ2 domains (grey and green) complex with syndecan-4 peptide (pink and yellow) (PDB id [[1ybo]]) ' scene=''> | <StructureSection load='1ybo' size='340' side='right' caption='Human syntenin PDZ1+PDZ2 domains (grey and green) complex with syndecan-4 peptide (pink and yellow) (PDB id [[1ybo]]) ' scene=''> | ||
| - | This is a default text for your page '''Syntenin'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
| - | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
== Function == | == Function == | ||
| - | + | '''Syntenin''' (SYNT) is a small intracellular adaptor which together with syndecan has a role in the biogenesis of secreted vesicles or exosomes<ref>PMID:26032692</ref> | |
== Relevance == | == Relevance == | ||
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| + | Exosomes secreted by cancer cells contribute to tumor progression and metastasis and analyzing their content can help in early detection of cancer as well as of other diseases. SYNT is over-expressed in breast and gastric cancer | ||
== Structural highlights == | == Structural highlights == | ||
| - | + | The 3D structure of the complex of SYNT PDZ1 and PDZ2 domains with a syndecan peptide shows the simultaneous binding to the two domains<ref>PMID:16533050</ref>. The peptide forms a β strand which runs antiparallel to the PDZ β strand. | |
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| + | ==Syntenin 3D structures== | ||
| + | [[3D structures of syntenin]] | ||
</StructureSection> | </StructureSection> | ||
Revision as of 10:31, 29 June 2022
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References
- ↑ Friand V, David G, Zimmermann P. Syntenin and syndecan in the biogenesis of exosomes. Biol Cell. 2015 Oct;107(10):331-41. doi: 10.1111/boc.201500010. Epub 2015 Jun 30. PMID:26032692 doi:http://dx.doi.org/10.1111/boc.201500010
- ↑ Grembecka J, Cierpicki T, Devedjiev Y, Derewenda U, Kang BS, Bushweller JH, Derewenda ZS. The binding of the PDZ tandem of syntenin to target proteins. Biochemistry. 2006 Mar 21;45(11):3674-83. PMID:16533050 doi:10.1021/bi052225y
