Syntenin

Function

Syntenin (SYNT) is a small intracellular adaptor which together with syndecan has a role in the biogenesis of secreted vesicles or exosomes^[1]

Relevance

Exosomes secreted by cancer cells contribute to tumor progression and metastasis and analyzing their content can help in early detection of cancer as well as of other diseases. SYNT is over-expressed in breast and gastric cancer

Structural highlights

The 3D structure of the complex of SYNT PDZ1 and PDZ2 domains with a syndecan peptide shows the simultaneous binding to the two domains^[2]. The peptide forms a β strand which runs antiparallel to the PDZ β strand.

Syntenin 3D structures

3D structures of syntenin