DNA mismatch repair protein
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | '''DNA mismatch repair proteins''' are key players in genomic stability by signalling mismatches occurring during DNA replication and recombination<ref>PMID: | + | '''DNA mismatch repair proteins''' are key players in genomic stability by signalling mismatches occurring during DNA replication and recombination<ref>PMID:18157157</ref> .<br/> |
'''MutS''' is prokaryotic and recognizes base-base mismatches and small insertion/deletion mispairs<ref>PMID:11048711</ref> .<br /> | '''MutS''' is prokaryotic and recognizes base-base mismatches and small insertion/deletion mispairs<ref>PMID:11048711</ref> .<br /> | ||
'''MutL''' enhances recognition of mismatches<ref>PMID:15470502</ref> <br /> | '''MutL''' enhances recognition of mismatches<ref>PMID:15470502</ref> <br /> | ||
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== Disease == | == Disease == | ||
| - | <ref>PMID:18406444</ref> | + | Mutations in DNA mismatch repair proteins cause hereditary colorectal cancer and loss of these proteins cause significant fraction of sporadic cancers<ref>PMID:18406444</ref>. |
== Relevance == | == Relevance == | ||
Revision as of 09:42, 30 June 2022
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References
- ↑ Li GM. Mechanisms and functions of DNA mismatch repair. Cell Res. 2008 Jan;18(1):85-98. doi: 10.1038/cr.2007.115. PMID:18157157 doi:http://dx.doi.org/10.1038/cr.2007.115
- ↑ Lamers MH, Perrakis A, Enzlin JH, Winterwerp HH, de Wind N, Sixma TK. The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch. Nature. 2000 Oct 12;407(6805):711-7. PMID:11048711 doi:10.1038/35037523
- ↑ Guarne A, Ramon-Maiques S, Wolff EM, Ghirlando R, Hu X, Miller JH, Yang W. Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair. EMBO J. 2004 Oct 27;23(21):4134-45. Epub 2004 Oct 7. PMID:15470502
- ↑ Ellison AR, Lofing J, Bitter GA. Human MutL homolog (MLH1) function in DNA mismatch repair: a prospective screen for missense mutations in the ATPase domain. Nucleic Acids Res. 2004 Oct 8;32(18):5321-38. doi: 10.1093/nar/gkh855. Print, 2004. PMID:15475387 doi:http://dx.doi.org/10.1093/nar/gkh855
- ↑ Hsieh P, Yamane K. DNA mismatch repair: molecular mechanism, cancer, and ageing. Mech Ageing Dev. 2008 Jul-Aug;129(7-8):391-407. doi: 10.1016/j.mad.2008.02.012., Epub 2008 Mar 4. PMID:18406444 doi:http://dx.doi.org/10.1016/j.mad.2008.02.012
