Factor XII
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | The 3D structure of the complex between human FXIIa and a cyclic peptide inhibitor<ref>PMID:34723512</ref> shows the peptide forming <scene name='91/916250/Cv/6'>intermolecular β-sheet-like hydrogen bonds with FXIIa at two regions</scene>. Contacting residues of human FXIIa and cyclic peptide inhibitor are shown at ball-and-stick representation and colored deep sky blue and green, respectively. | + | The 3D structure of the complex between human FXIIa and a cyclic peptide inhibitor<ref>PMID:34723512</ref> shows the peptide forming <scene name='91/916250/Cv/6'>intermolecular β-sheet-like hydrogen bonds with FXIIa at two regions</scene>. Contacting residues of human FXIIa and cyclic peptide inhibitor are shown at ball-and-stick representation and colored deep sky blue and green, respectively. <scene name='91/916250/Cv/7'>Another representation</scene> of the complex between human FXIIa and a cyclic peptide inhibitor. |
==FXII 3D structures== | ==FXII 3D structures== | ||
Current revision
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References
- ↑ Renne T, Schmaier AH, Nickel KF, Blomback M, Maas C. In vivo roles of factor XII. Blood. 2012 Nov 22;120(22):4296-303. doi: 10.1182/blood-2012-07-292094. Epub 2012, Sep 19. PMID:22993391 doi:http://dx.doi.org/10.1182/blood-2012-07-292094
- ↑ Nickel KF, Long AT, Fuchs TA, Butler LM, Renne T. Factor XII as a Therapeutic Target in Thromboembolic and Inflammatory Diseases. Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):13-20. doi:, 10.1161/ATVBAHA.116.308595. Epub 2016 Nov 10. PMID:27834692 doi:http://dx.doi.org/10.1161/ATVBAHA.116.308595
- ↑ Liu W, de Veer SJ, Huang YH, Sengoku T, Okada C, Ogata K, Zdenek CN, Fry BG, Swedberg JE, Passioura T, Craik DJ, Suga H. An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human beta-Factor XIIa in a Cyclotide Scaffold. J Am Chem Soc. 2021 Nov 10;143(44):18481-18489. doi: 10.1021/jacs.1c07574. Epub, 2021 Nov 1. PMID:34723512 doi:http://dx.doi.org/10.1021/jacs.1c07574
