Syntenin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 11: Line 11:
== Structural highlights ==
== Structural highlights ==
-
The 3D structure of the complex of SYNT PDZ1 and PDZ2 domains with a syndecan peptide shows the <scene name='91/916387/Cv/2'>simultaneous binding to the two domains</scene><ref>PMID:16533050</ref>. The peptide forms a β strand which runs antiparallel to the PDZ β strand.
+
The 3D structure of the complex of SYNT PDZ1 and PDZ2 domains with a syndecan peptide shows the <scene name='91/916387/Cv/2'>simultaneous binding to the two domains</scene><ref>PMID:16533050</ref>. The peptide forms a β strand which runs antiparallel to the PDZ β strand. <scene name='91/916387/Cv/3'>Syntenin/Syndecan peptide inreactions</scene>.
==Syntenin 3D structures==
==Syntenin 3D structures==

Revision as of 13:18, 5 July 2022

Human syntenin PDZ1+PDZ2 domains (deep sky blue and green) complex with syndecan-4 peptide (pink and yellow) (PDB id 1ybo)

Drag the structure with the mouse to rotate

References

  1. Friand V, David G, Zimmermann P. Syntenin and syndecan in the biogenesis of exosomes. Biol Cell. 2015 Oct;107(10):331-41. doi: 10.1111/boc.201500010. Epub 2015 Jun 30. PMID:26032692 doi:http://dx.doi.org/10.1111/boc.201500010
  2. Grembecka J, Cierpicki T, Devedjiev Y, Derewenda U, Kang BS, Bushweller JH, Derewenda ZS. The binding of the PDZ tandem of syntenin to target proteins. Biochemistry. 2006 Mar 21;45(11):3674-83. PMID:16533050 doi:10.1021/bi052225y

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

Personal tools