1fli
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(New page: 200px<br /> <applet load="1fli" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fli" /> '''DNA-BINDING DOMAIN OF FLI-1'''<br /> ==Ove...)
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Revision as of 14:48, 12 November 2007
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DNA-BINDING DOMAIN OF FLI-1
Overview
Members of the ets family of transcription factors share a conserved, DNA-binding domain, the ets domain. By using multidimensional NMR, we have, determined the structure of the ets domain of human Fli-1 in the DNA-bound, form. It consists of three alpha-helices and a four-stranded beta-sheet, similar to structures of the class of helix-turn-helix DNA binding, proteins first found in the catabolite activator protein of Escherichia, coli. NMR and mutagenesis experiments suggest that in comparison to, structurally related proteins, the ets domain uses a new variation of the, helix-turn-helix motif for binding to DNA.
About this Structure
1FLI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of the ets domain of Fli-1 when bound to DNA., Liang H, Mao X, Olejniczak ET, Nettesheim DG, Yu L, Meadows RP, Thompson CB, Fesik SW, Nat Struct Biol. 1994 Dec;1(12):871-5. PMID:7773776
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