7wz8
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Structure of human langerin complex in Birbeck granules== | ==Structure of human langerin complex in Birbeck granules== | ||
| - | <StructureSection load='7wz8' size='340' side='right'caption='[[7wz8]]' scene=''> | + | <StructureSection load='7wz8' size='340' side='right'caption='[[7wz8]], [[Resolution|resolution]] 6.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WZ8 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7wz8]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WZ8 FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wz8 OCA], [https://pdbe.org/7wz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wz8 RCSB], [https://www.ebi.ac.uk/pdbsum/7wz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wz8 ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wz8 OCA], [https://pdbe.org/7wz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wz8 RCSB], [https://www.ebi.ac.uk/pdbsum/7wz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wz8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Langerhans cells are specialized antigen-presenting cells localized within the epidermis and mucosal epithelium. Upon contact with Langerhans cells, pathogens are captured by the C-type lectin langerin and internalized into a structurally unique vesicle known as a Birbeck granule. Although the immunological role of Langerhans cells and Birbeck granules have been extensively studied, the mechanism by which the characteristic zippered membrane structure of Birbeck granules is formed remains elusive. In this study, we observed isolated Birbeck granules using cryo-electron tomography and reconstructed the 3D structure of the repeating unit of the honeycomb lattice of langerin at 6.4 A resolution. We found that the interaction between the two langerin trimers was mediated by docking the flexible loop at residues 258-263 into the secondary carbohydrate-binding cleft. Mutations within the loop inhibited Birbeck granule formation and the internalization of HIV pseudovirus. These findings suggest a molecular mechanism for membrane zippering during Birbeck granule biogenesis and provide insight into the role of langerin in the defense against viral infection. | ||
| + | |||
| + | Cryo-electron tomography of Birbeck granules reveals the molecular mechanism of langerin lattice formation.,Oda T, Yanagisawa H, Shinmori H, Ogawa Y, Kawamura T Elife. 2022 Jun 27;11. pii: 79990. doi: 10.7554/eLife.79990. PMID:35758632<ref>PMID:35758632</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7wz8" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Oda T]] | + | [[Category: Oda, T]] |
| - | [[Category: Yanagisawa H]] | + | [[Category: Yanagisawa, H]] |
| + | [[Category: Birbeck granule]] | ||
| + | [[Category: C-type lectin]] | ||
| + | [[Category: Langerhans cell]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Virus defense]] | ||
Revision as of 16:27, 6 July 2022
Structure of human langerin complex in Birbeck granules
| |||||||||||
