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3t2n

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Current revision (16:40, 6 July 2022) (edit) (undo)
 
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==Human hepsin protease in complex with the Fab fragment of an inhibitory antibody==
==Human hepsin protease in complex with the Fab fragment of an inhibitory antibody==
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<StructureSection load='3t2n' size='340' side='right' caption='[[3t2n]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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<StructureSection load='3t2n' size='340' side='right'caption='[[3t2n]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3t2n]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T2N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T2N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3t2n]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T2N FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1z8g|1z8g]], [[1o5e|1o5e]], [[1p57|1p57]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1z8g|1z8g]], [[1o5e|1o5e]], [[1p57|1p57]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HPN, TMPRSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HPN, TMPRSS1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hepsin Hepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.106 3.4.21.106] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Hepsin Hepsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.106 3.4.21.106] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t2n OCA], [http://pdbe.org/3t2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3t2n RCSB], [http://www.ebi.ac.uk/pdbsum/3t2n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3t2n ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t2n OCA], [https://pdbe.org/3t2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t2n RCSB], [https://www.ebi.ac.uk/pdbsum/3t2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t2n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HEPS_HUMAN HEPS_HUMAN]] Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL.<ref>PMID:21875933</ref> <ref>PMID:15839837</ref>
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[[https://www.uniprot.org/uniprot/HEPS_HUMAN HEPS_HUMAN]] Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL.<ref>PMID:21875933</ref> <ref>PMID:15839837</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[3D structures of monoclonal antibody|3D structures of monoclonal antibody]]
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Hepsin]]
[[Category: Hepsin]]
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Auer, J]]
[[Category: Auer, J]]
[[Category: Cramer, P]]
[[Category: Cramer, P]]

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Human hepsin protease in complex with the Fab fragment of an inhibitory antibody

PDB ID 3t2n

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