3t6a

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==Structure of the C-terminal domain of BCAR3==
==Structure of the C-terminal domain of BCAR3==
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<StructureSection load='3t6a' size='340' side='right' caption='[[3t6a]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='3t6a' size='340' side='right'caption='[[3t6a]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3t6a]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T6A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T6A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3t6a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T6A FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=POG:(20S)-2,5,8,11,14,17-HEXAMETHYL-3,6,9,12,15,18-HEXAOXAHENICOSANE-1,20-DIOL'>POG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=POG:(20S)-2,5,8,11,14,17-HEXAMETHYL-3,6,9,12,15,18-HEXAOXAHENICOSANE-1,20-DIOL'>POG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3t6g|3t6g]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3t6g|3t6g]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCAR3, NSP2, SH2D3B, UNQ271/PRO308 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCAR3, NSP2, SH2D3B, UNQ271/PRO308 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t6a OCA], [http://pdbe.org/3t6a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3t6a RCSB], [http://www.ebi.ac.uk/pdbsum/3t6a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3t6a ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t6a OCA], [https://pdbe.org/3t6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t6a RCSB], [https://www.ebi.ac.uk/pdbsum/3t6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t6a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BCAR3_HUMAN BCAR3_HUMAN]] May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins.<ref>PMID:9582273</ref>
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[[https://www.uniprot.org/uniprot/BCAR3_HUMAN BCAR3_HUMAN]] May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins.<ref>PMID:9582273</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Mace, P D]]
[[Category: Mace, P D]]
[[Category: Riedl, S J]]
[[Category: Riedl, S J]]

Revision as of 16:44, 6 July 2022

Structure of the C-terminal domain of BCAR3

PDB ID 3t6a

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