1hml

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[[Image:1hml.gif|left|200px]]
[[Image:1hml.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1hml |SIZE=350|CAPTION= <scene name='initialview01'>1hml</scene>, resolution 1.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1hml", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Lactose_synthase Lactose synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.22 2.4.1.22] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1hml| PDB=1hml | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hml OCA], [http://www.ebi.ac.uk/pdbsum/1hml PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hml RCSB]</span>
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}}
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'''ALPHA_LACTALBUMIN POSSESSES A DISTINCT ZINC BINDING SITE'''
'''ALPHA_LACTALBUMIN POSSESSES A DISTINCT ZINC BINDING SITE'''
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[[Category: Ren, J.]]
[[Category: Ren, J.]]
[[Category: Stuart, D I.]]
[[Category: Stuart, D I.]]
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[[Category: calcium-binding protein]]
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[[Category: Calcium-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:01:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:07:43 2008''
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Revision as of 16:01, 2 May 2008

Image:1hml.gif

Template:STRUCTURE 1hml

ALPHA_LACTALBUMIN POSSESSES A DISTINCT ZINC BINDING SITE


Overview

It has been proposed that the binding of Zn2+ to alpha-lactalbumin switches the conformation to one akin to a state intermediate in the folding of the protein. However, the high resolution x-ray crystal structure of human alpha-lactalbumin-Zn2+ complex at 1.7-A resolution (pH 7.6) does not reveal any significant change in conformation from the native state. The Zn2+ ion binds specifically in the "cleft" of alpha-lactalbumin (the region which forms the active site of the homologous protein lysozyme). This may suggest a possible role for Zn2+ binding in lactose synthase complex. The coordination of the Zn2+ ion involves a symmetry-related molecule in the crystal, the crystal contacts being stabilized by a SO4(2-) ion bound at the interface between three molecules.

About this Structure

1HML is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Alpha-lactalbumin possesses a distinct zinc binding site., Ren J, Stuart DI, Acharya KR, J Biol Chem. 1993 Sep 15;268(26):19292-8. PMID:8366079 Page seeded by OCA on Fri May 2 19:01:06 2008

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