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1hmy

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[[Image:1hmy.jpg|left|200px]]
[[Image:1hmy.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1hmy |SIZE=350|CAPTION= <scene name='initialview01'>1hmy</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1hmy", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_(cytosine-5-)-methyltransferase DNA (cytosine-5-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.37 2.1.1.37] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1hmy| PDB=1hmy | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hmy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hmy OCA], [http://www.ebi.ac.uk/pdbsum/1hmy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hmy RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THE HHAL DNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYL-L-METHIONINE'''
'''CRYSTAL STRUCTURE OF THE HHAL DNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYL-L-METHIONINE'''
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==Reference==
==Reference==
Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine., Cheng X, Kumar S, Posfai J, Pflugrath JW, Roberts RJ, Cell. 1993 Jul 30;74(2):299-307. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8343957 8343957]
Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine., Cheng X, Kumar S, Posfai J, Pflugrath JW, Roberts RJ, Cell. 1993 Jul 30;74(2):299-307. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8343957 8343957]
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[[Category: DNA (cytosine-5-)-methyltransferase]]
 
[[Category: Haemophilus haemolyticus]]
[[Category: Haemophilus haemolyticus]]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Cheng, X.]]
[[Category: Cheng, X.]]
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[[Category: transferase(methyltransferase)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:01:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:07:48 2008''
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Revision as of 16:01, 2 May 2008

Image:1hmy.jpg

Template:STRUCTURE 1hmy

CRYSTAL STRUCTURE OF THE HHAL DNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYL-L-METHIONINE


Overview

The first three-dimensional structure of a DNA methyltransferase is presented. The crystal structure of the DNA (cytosine-5)-methyltransferase, M.HhaI (recognition sequence: GCGC), complexed with S-adenosyl-L-methionine has been determined and refined at 2.5 A resolution. The core of the structure is dominated by sequence motifs conserved among all DNA (cytosine-5)-methyltransferases, and these are responsible for cofactor binding and methyltransferase function.

About this Structure

1HMY is a Single protein structure of sequence from Haemophilus haemolyticus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine., Cheng X, Kumar S, Posfai J, Pflugrath JW, Roberts RJ, Cell. 1993 Jul 30;74(2):299-307. PMID:8343957 Page seeded by OCA on Fri May 2 19:01:36 2008

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