Gasdermin
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='6cb8' size='340' side='right' caption='Caption for this structure' scene=''> '''Gasdermin''' (GSDM) is the substrate of the inflamamatory Caspase downstream f...) |
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| - | + | <StructureSection load='6cb8' size='340' side='right' caption='Cryo-EM mouse gasdermin A3 pore complex with cardiolipin (PDB code [[6cb8]])' scene=''> | |
| - | <StructureSection load='6cb8' size='340' side='right' caption=' | + | '''Gasdermin''' (GSDM) is the substrate of the inflamamatory [[Caspase]] downstream from inflamasomes which activate caspase. Inflammasomes are supramolecular signaling assemblies activating the lytic process against exogenous pathogens. GSDM is required for cytokine release and pyroptosis <ref>PMID:31451512</ref>. Pyropptosis is the regulated lytic cell death mediated by GSMD pore formation. GSDM D contains 2 domains: the N-terminal fragment which is pore-forming and the repressive C-terminal. The GSDM family contains 6 members in human. |
| - | '''Gasdermin''' (GSDM) is the substrate of the inflamamatory [[Caspase]] downstream from inflamasomes which activate caspase. GSDM is required for cytokine release and pyroptosis <ref>PMID:31451512</ref>. Pyropptosis is the regulated lytic cell death mediated by GSMD pore formation. GSDM D contains 2 domains: the N-terminal fragment which is pore-forming and the repressive C-terminal. The GSDM family contains 6 members in human | + | |
== Function == | == Function == | ||
Revision as of 09:37, 11 July 2022
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References
- ↑ Xia S, Hollingsworth LR 4th, Wu H. Mechanism and Regulation of Gasdermin-Mediated Cell Death. Cold Spring Harb Perspect Biol. 2020 Mar 2;12(3). pii: cshperspect.a036400. doi: , 10.1101/cshperspect.a036400. PMID:31451512 doi:http://dx.doi.org/10.1101/cshperspect.a036400
